PNH is considered chronic. That means it lasts for a long time. The only known cure is a bone marrow transplant. Other treatments are designed to ease symptoms and prevent problems. A small number of people say their PNH went away on its own over time.

Treating Hemolysis and Anemia

For most people with PNH, the most common problem is anemia caused by hemolysis. Here are some treatments for hemolysis and anemia.

Blood Transfusions

In a blood transfusion, whole blood or parts of blood from a donor are put right into your bloodstream. This can improve your anemia. Your doctor will look at your symptoms to decide if you need a transfusion.

The 2 types of transfusion available for PNH patients are:

Learn more about blood transfusions.

Iron Therapy

Hemolysis can lead to a shortage of iron in your body. This can make it hard for your bone marrow to make red blood cells. So, unless you are receiving regular red blood cell transfusions, you probably need to take iron pills. Ask your doctor how much iron you need. 

Side Effects of Iron Therapy

At first, taking iron pills can cause hemolysis, which leads to dark urine. This happens because your bone marrow is making more red blood cells. Some of them break apart because you have PNH.

Iron pills can also cause an upset stomach. If you have a severe stomach problem, you can receive your iron by injection. There is a very small risk of allergic reaction when iron is given this way.

Folate and Folic Acid

Folate is a B-vitamin that is found in fresh or lightly cooked green vegetables. It helps your bone marrow make normal blood cells. When your bone marrow has to make more cells, it needs a larger supply of folic acid.

Most people get enough folate in their diet. But if you have PNH, it's a good idea to take 1 mg each day of a man-made form of folate called folic acid.

Growth Factors

Growth factors are chemicals in your body. They cause your bone marrow to make blood cells.  Man-made forms of some growth factors are available. They can reduce the need for red blood cell transfusion. Learn more.


Androgens are natural male hormones that can cause your bone marrow to make more red blood cells. This can improve anemia. Androgens are more likely to be used if you have other bone marrow failure problems besides PNH. Learn more.

Treating Bone Marrow Failure

Bone marrow failure is a condition in which your bone marrow does not make enough healthy cells. In people who have PNH, bone marrow failure is most likely to be caused by aplastic anemia. So the treatment for bone marrow failure is the same as that for aplastic anemia.  Read more about aplastic anemia.

Bone Marrow Transplantation

If other treatments have not worked to stop hemolysis, clotting, or bone marrow failure, then a bone marrow transplant may be the next step.

In this procedure, healthy bone marrow stem cells and other bone marrow cells are taken from a donor. These cells are given by IV. The donor's cells make their way through your blood and into your bones where they start making healthy blood cells.

Bone marrow transplantation is the only way to cure PNH. But it carries many risks, including death.

Read more about bone marrow and stem cell transplantation.


Patients with PNH should receive vaccinations against certain types of bacteria to prevent infection. Ask your doctor which ones are right for you.

Always ask your hematologist about all treatment options available to you.

Order an AA&MDSIF information packet containing detailed information about PNH and its treatment. This packet includes questions that need to be answered by your doctor before you agree to any treatment option.

For more in-depth information on PNH and its treatment, you can also visit our Online Learning Center, and view webinars by some of the leading medical experts on PNH.