Myelodysplastic Syndromes Clinical Trials

Not all trials are listed on www.ClinicalTrials.gov. The investigators may have chosen not to register the trial, or the study may not be eligible to be listed on ClinicalTrials.gov. If the study has not, for example, been approved by a human subject review board, it cannot be posted. Some trials are not listed because the investigators are not planning to publish the research findings, so you can ask the study coordinator why the study has not been included on ClinicalTrials.gov before you give your consent to participate.

The information on the studies linked below is provided strictly as a resource, not as an endorsement of any given treatment, doctor, or medical center.

Remember, before you sign a consent form, Clinical Trials Explained can help you understand the potential risks and benefits of a clinical trial. You can also contact the AA&MDSIF staff to discuss any questions you have at clinicaltrials@aamds.org or by calling the office at 301.279.7202 or 800.747.2820.

^{Last Modified: February 2009}

Memorial Sloan Kettering Cancer Center

A Phase I/II Study of Decitabine and All-Trans Retinoic Acid (Tretinoin) for Patients with Myelodysplastic Syndromes

Protocol 06-054 | New York, New York

This is a phase I/II study combining the FDA-approved intravenous medication called decitabine with a pill called tretinoin in patients with MDS. The goals of the study are to see if this combination is safe and if it improves the bone marrow function and blood counts in people with MDS. Eligible patients must have MDS with an IPSS score of 0.5 or greater, as well as adequate kidney and liver function. If 5-azacytidine was previously received, and it did not work, then you may not be eligible for this trial. For more information contact Virginia Klimek, MD, Principal Investigator, at 212.639.6519 or klimekv@mskcc.org and visit www.mskcc.org.

For information from Clinicaltrials.gov, visit: http://www.clinicaltrials.gov/ct2/show/NCT00382200?term=A+Phase+I%2FII+Study+of+Decitabine+and+All-Trans+Retinoic+Acid+%28Tretinoin%29+for+Patients+with+Myelodysplastic+Syndromes&rank=1

For patients with: MDS

Link: http://www.mskcc.org/mskcc/html/2270.cfm?IRBNO=06-054

Updated: December 11, 2007

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