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Treatment with imetelstat, a competitive inhibitor of telomerase enzymatic activity, was associated with a clinically meaningful rate of transfusion independence in heavily transfused patients with lower-risk
Abstract
Key Points
Different metabolic pathways are involved in intracellular metabolic reprogramming depending on the genetic characteristics of AML cells.
Leukemic progenitors activate different programs of the metabolism, depending on their levels of differentiation blockade.
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Dear members of the PNH community,
Results from the phase III PEGASUS trial suggest that the targeted C3 inhibitor pegcetacoplan improved hemoglobin levels better than eculizumab in patients with
