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treatment

APR-246

A methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, PRIMA-1 analog APR-246 covalently modifies the core domain of mutated forms of cellular tumor antigen p53 (p53) through the alkylation of thiol groups.

Ashley and Alayna: A Mother's Story

Person's Name: 
Ashley Numbers

September 16 through December 20 will stand out in Ashley’s mind.

Forever.

These are the days she spent in the hospital with her feisty three-year-old, Alayna, for conditioning and bone marrow transplant.

The summer of 2019 was already big with a wedding to plan.  The toddler and her baby brother were enjoying everything that small ones do, including riding dirt bikes with Daddy.

Bone Marrow Disease(s): 
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