Grants and Grant Recipients
Since 1989, AAMDSIF has provided research grants totaling in excess of $5.9 million to an international group of 107 researchers
The two-year grants have helped bring forth new insights into the causes and therapeutic approaches for these diseases. These grantee profiles present the grantees by year the awards were granted, and a summary of their grant-funded research projects.
Grant Year: 2011
Parinda Mehta, MD
Trinity Ewert Research Fund
Dr. Mehta will study the use of Quercetin, a naturally occurring flavonoid (antioxidant) in patients with Fanconi anemia, one of the most common congenital bone marrow failure syndromes. She anticipates that the results of this pilot study will show that long term oral Quercetin therapy is feasible and well tolerated in patients with Fanconi anemia. These results will form the basis of the continuation phase of the study, which will demonstrate that Quercetin therapy in fact delays or prevents progressive marrow failure in children with Fanconi anemia.
Mridul Mukherji, DPhil
Harold Spielberg Research Fund
TET2 is one of the most frequently mutated genes identified in patients with myelodysplastic syndromes (MDS). This study will help explore new avenues for the cure TET2 mutations, and Dr. Mukherji says he and his colleagues “will use our expertise to develop strategies to restore TET2 activity for the treatment of MDS.”
Grant Year: 2010
Grant Year: 2009
Grant Year:
Simona Pagliuca, MD
Arthur Kunofsky Research Fund
RACE is a phase III randomized study initiated in 2015 whose aim was to evaluate whether the standard first-line therapy for severe aplastic anemia (anti-thymoglobuline and cyclosporine) could be improved by the addition of eltrombopag, a small molecule previously showing a promising effect in stimulating hematopoiesis.
The purpose of the present translational research was to understand how the aberrant immune response characterizing aplastic anemia could be modified by the introduction of eltrombopag.
RACE trial has recently concluded and results are under publication.