Myelodysplastic Syndromes (MDS)

Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia

Original Publication Date

November 18, 2025

Article Source

External Web Content

Abstract Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP) and progression to myelodysplastic syndromes (MDS). Using single-cell and anatomical profiling of a large cohort of human bone marrow (BM)…

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

Original Publication Date

November 5, 2025

Article Source

External Web Content

Key Points Ivosidenib, venetoclax ± azacitidine either rapidly selects evolved, resistant leukemic clones or eradicates leukemic clones. Resistant clones express RNA signatures of stemness, branched-chain amino acid metabolism, and menin targets. Subjects:Myeloid Neoplasia…

Infections in lower-risk myelodysplastic syndromes - prevalence and risk factors: a report from the European MDS Registry

Read more about Infections in lower-risk myelodysplastic syndromes - prevalence and risk factors: a report from the European MDS Registry

Infections are an important cause of morbidity and mortality in patients with lower-risk myelodysplastic syndromes myelodysplastic syndromes:

Optimal timing of allogeneic hematopoietic stem cell transplant in MDS

Read more about Optimal timing of allogeneic hematopoietic stem cell transplant in MDS

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis hematopoiesis: (hi-mat-uh-poy-EE-suss) The process of making blood cells in

Understanding Aplastic Anemia and Overlapping Diseases

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Learn more about the connection between aplastic anemia and other bone marrow failure diseases.

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Not all healthcare professionals or emergency responders will understand your rare diagnosis and unique needs. AAMDSIF has created an emergency health information card that communicates to others what they need to know…

10th International Bone Marrow Failure Disease Scientific Symposium

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Topic(s)

Aplastic Anemia

Myelodysplastic Syndromes (MDS)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

The 10th International Bone Marrow Failure Disease Scientific Symposium will convene physicians, laboratory researchers and clinical investigators to discuss current areas of consensus and controversy, share recent research results, and clarify promising directions for…

ASH 2021 MDS and AML - for Patients

This publication offers summaries of selected abstracts presented at the December 2021 Meeting of the American Hematology Society. It provides new and updated information about new research into the diagnosis, treatment…

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Myelodysplastic Syndromes (MDS)

Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

Infections in lower-risk myelodysplastic syndromes - prevalence and risk factors: a report from the European MDS Registry

Optimal timing of allogeneic hematopoietic stem cell transplant in MDS

Understanding Aplastic Anemia and Overlapping Diseases

Transplant Patient Card

Non Transplant Patient Card

Instructions

10th International Bone Marrow Failure Disease Scientific Symposium

ASH 2021 MDS and AML - for Patients

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