What is MDS
Basic description of MDS and how it affects your bone marrow and blood
Myelodysplastic Syndromes (MDS)
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Study Connects Agent Orange Exposure to Earlier and More Severe Cases of Myelodysplastic Syndrome
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Summary Many veterans and doctors have long questioned whether Agent Orange (AO) exposure during the Vietnam War contributed to cases of myelodysplastic syndrome (MDS), a type of blood cancer. The contaminated chemical is linked to several cancers, but a link to MDS was unclear…
Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia
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Abstract Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP) and progression to myelodysplastic syndromes (MDS). Using single-cell and anatomical profiling of a large cohort of human bone marrow (BM)…
Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
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Key Points Ivosidenib, venetoclax ± azacitidine either rapidly selects evolved, resistant leukemic clones or eradicates leukemic clones. Resistant clones express RNA signatures of stemness, branched-chain amino acid metabolism, and menin targets. Subjects:Myeloid Neoplasia…
Infections in lower-risk myelodysplastic syndromes - prevalence and risk factors: a report from the European MDS Registry
Infections are an important cause of morbidity and mortality in patients with lower-risk myelodysplastic syndromes myelodysplastic syndromes:
Optimal timing of allogeneic hematopoietic stem cell transplant in MDS
Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis hematopoiesis: (hi-mat-uh-poy-EE-suss) The process of making blood cells in
Understanding Aplastic Anemia and Overlapping Diseases
Learn more about the connection between aplastic anemia and other bone marrow failure diseases.
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