Chronic Myelomonocytic Leukaemia (CMML)

Health-Related Quality of Life, AAMDSIF 2026 International Bone Marrow Failure Scientific Symposium

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Presenter(s)
Namrata Chandhok, MD
Thomas LeBlanc, MD, MA
Fabio Efficace, PhD
Alison R. Kavanaugh
Pamela C. Egan, MD
Wil L. Santivasi, MD
The session was recorded at the AAMDSIF 2026 International Bone Marrow Failure Scientific Symposium, Co-Chairs Namrata Chandhok, MD, and Thomas LeBlanc, MD, MA Topics and speakers included: How can we measure quality of life in MDS, to inform interventions? - Fabio Efficace, PhD…

Non-Transplant Therapies for Marrow Failure, AAMDSIF 2026 International Bone Marrow Failure Scientific Symposium

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Presenter(s)
Carlos DeCastro, MD
Phil Scheinberg, MD
Regis Peffault de Latour, MD, PhD
Julian Sevilla, MD, PhD
Kasiani Myers, MD
Suneet Agarwal, MD, PhD
This session was presented at the AAMDSIF 2026 International Bone Marrow Failure Scientific Symposium; Co-Chairs Carlos DeCastro, MD, and Phil Scheinberg, MD, PhD. Session topics included: -Androgens, alemtuzumab, anti-cytokine therapies (anti-IL2R, anti-IFN gamma), daratumumab…

Isolated KRAS and NRAS mutations in adults with monocytosis and/or cytopenia(s)

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Abstract NRAS and KRAS mutations, commonly identified alongside ancestral co-mutations, are generally regarded as pathogenic in adults presenting with monocytosis and/or cytopenia(s). However, their significance in isolation is not well defined. We studied a multi-institutional…

Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells

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Abstract Improved ex vivo expansion of human haematopoietic stem cells (HSCs) would considerably advance transplantation and genome-engineered therapies, yet existing culture methods still allow substantial HSC loss. Here we show that this attrition is driven largely by…

Oral Decitabine/Cedazuridine Plus Venetoclax Yields 91% ORR in High-Risk MDS and CMML

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Key Takeaways The combination therapy achieved a 91% overall response rate, with 45% complete remission and 46% marrow complete remission rates. Median overall survival was 30 months, with 1- and 3-year survival rates of 68.8% and 40.7%, respectively. SHOW MORE Decitabine…

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