News and Treatment Updates

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

How I Treat Higher-Risk MDS with Alain Mina, Rami S. Komrokji

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Myelodysplastic syndromes/neoplasms (MDS) are a widely heterogenous group of myeloid malignancies characterized by morphologic dysplasia, a defective hematopoiesis, and recurrent genetic abnormalities. The original and revised International Prognostic Scoring Systems (IPSS) have…

Iron accelerates MDS progression

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In this issue of Blood, Antypiuk et al, utilizing a murine model, demonstrate that iron overload (IOL), accumulated via a mutation in the iron importer ferroportin, accelerates the myelodysplastic syndrome (MDS) phenotype, leading to exacerbation of marrow failure, inferior…

Early Findings on Ziftomenib With Chemotherapy in AML From KOMET-007 Trial

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Ziftomenib plus standard cytarabine and daunorubicin chemotherapy was well tolerated with consistent safety and continued to show “robust clinical activity” in patients newly diagnosed with NPM1-mutated (NPM1-m) or KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML)…

State of the Art Treatment in Myelodysplastic Syndromes

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Presenter: Mikkael Sekeres Professor of Medicine, Chief, Division of Hematology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine Miami, FL, USA Release Date: December 20, 2024 Congress: ASH 2024 Area: Hematology Description: Mikkael A. Sekeres…

Allogeneic Hematopoietic Cell Transplantation for the Treatment of Severe Aplastic Anemia: Evidence-Based Guidelines From the American Society for Transplantation and Cellular Therapy

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Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment for severe aplastic anemia (SAA). Existing guidance about HCT in SAA is primarily derived from expert reviews, registry data and societal guidelines; however, transplant-specific guidelines…

Therapy for acute myeloid leukemia in older and unfit adults

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TITLE Azacitidine and venetoclax in previously untreated acute myeloid leukemia. AUTHORS DiNardo CD, Jonas BA, Pullarkat V, et al. JOURNAL The New England Journal of Medicine. 2020;383:617-629. doi: 10.1056/NEJMoa2012971. The therapy of acute myeloid leukemia (AML) has…

Can JAK inhibition prevent GVHD?

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In this issue of Blood, Pidala et al report on the results of a multicenter phase 2 trial, in which a graft-versus-host disease (GVHD) prevention regimen of pacritinib, an oral JAK2 inhibitor, in combination with sirolimus and tacrolimus successfully suppressed pSTAT3 signaling…

What have we learned about TP53-mutated acute myeloid leukemia?

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Abstract TP53 is a tumor suppressor gene frequently mutated in human cancers and is generally associated with poor outcomes. TP53 mutations are found in approximately 5% to 10% of patients with de novo acute myeloid leukemia (AML), more frequently observed in elderly patients and…

Risk prediction for clonal cytopenia: multicenter real-world evidence

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Key Points A 3-parameter CCRS model was devised specifically for patients diagnosed with clonal cytopenia. The CCRS offers precise CCUS risk assessment for patient management and clinical trial eligibility. Abstract Clonal cytopenia of undetermined significance (CCUS) represents…

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