The symptoms of bone marrow failure bone marrow failure: A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic anemia, myelodysplastic syndromes (MDS) and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be… diseases like aplastic anemia aplastic anemia: (ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells, white blood cells, and platelets. The term aplastic is a Greek word meaning not to form. Anemia is a condition that happens when red blood cell count is low. Most… , MDS and PNH are caused by low blood counts. The specific symptoms depend on which type of blood cell is affected. Read the section below to see the symptoms for each type of cell.
You may have many of these symptoms or just one or two of them. And you may get a new symptom at any point in the course of your illness.
Low Red Blood Cell Count
A low red blood cell red blood cell: The most numerous type of blood cell in healthy people. Red blood cells contain hemoglobin, a protein that picks up oxygen in the lungs and brings it to cells in all parts of the body. Also called erythrocyte, RBC. count is called anemia anemia: (uh-NEE-mee-uh) A condition in which there is a shortage of red blood cells in the bloodstream. This causes a low red blood cell count. Symptoms of anemia are fatigue and tiredness. . If you have a low red blood cell count, you may:
- Feel a little tired or very tired.
- Feel less alert or have trouble concentrating.
- Have a loss of appetite or lose weight.
- Have paler-than-normal skin.
- Have trouble breathing.
- Have rapid heartbeat.
- Have reduced ability to exercise or climb stairs.
Low White Blood Cell Count
A low white blood cell white blood cell: Cells in the body that fight disease and infection by attacking and killing germs. There are several types of white blood cells including neutrophils, eosinophils, basophils, lymphocytes and monocytes. Each type of cell fights a different kind of germ. Also called WBC, leukocyte. count is called neutropenia. If you have a low white blood cell count, you may:
- Have repeated fevers and infections.
- Get bladder infections that may make it painful to pass urine, or make you urinate more often.
- Get lung infections that cause coughing and difficulty breathing.
- Get mouth sores.
- Get sinus infections and a stuffy nose.
- Get skin infections.
Low Platelet Count
A low platelet platelet: The smallest type of blood cell. Platelets help the blood to clot and stop bleeding. Also called a thrombocyte. count is called thrombocytopenia. If you have a low platelet count, you may:
- Bruise or bleed more easily – even from minor scrapes and bumps.
- Get heavy menstrual periods.
- Get nose bleeds.
- Get tiny, flat red spots under your skin, which are caused by bleeding. These spots are called petechiae.
- Have bleeding gums, especially after dental work or from brushing your teeth. Check with your doctor before getting any dental work.