Myelodysplastic Syndromes (MDS)

Diagnosis of TP53-mutated myeloid disease by the ICC and WHO fifth edition classifications

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Key Points The ICC and WHO5 differently classify 64% of TP53-mutated disease due to distinct criteria for multihit TP53 mutations and TP53-mutated AML. MDS with a single TP53 mutation and CK is similar to MDS with biallelic TP53 abnormalities, whereas TP53-mutated AML is distinct…

ACROBAT interim results support AlloHeme for relapse prediction in AML, MDS

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Interim results of the ACROBAT study suggest that increasing microchimerism and loss of complete chimerism may indicate relapse risk in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The findings were presented in an oral abstract1 at the 2025…

Genome sequencing in the management of myelodysplastic syndromes and related disorders

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Abstract Myeloid neoplasms originate from the clonal proliferation of hematopoietic stem cells, which is driven by the acquisition of somatic genetic mutations. Within these disorders, myelodysplastic syndromes (MDS) are specifically characterized by morphological abnormalities…

Oppose 57% Cut to Congressionally Directed Medical Research Programs

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Community Impact
Oppose 57% Cut to Congressionally Directed Medical Research Programs Take Action Before House Vote Oppose 57% Cut to Congressionally Directed Medical Research Programs Tell your Members of Congress to Vote NO on The Full-Year Continuing Appropriations and Extensions Act, 2025 As…

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Letter on the Bipartisan Senate FY25 Labor-HHS-Education Appropriations Bill

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Coalition Action
AAMDSIF is Taking a Stand for NIH Research Research programs led by the National Institutes of Health (NIH) forge the way for life-saving new treatments for rare diseases such as aplastic anemia, MDS, and PNH. With clinical research locations throughout the U.S., researchers and…

State of the Art Treatment in Myelodysplastic Syndromes

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Presenter: Mikkael Sekeres Professor of Medicine, Chief, Division of Hematology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine Miami, FL, USA Release Date: December 20, 2024 Congress: ASH 2024 Area: Hematology Description: Mikkael A. Sekeres…

Life After MDS and Accomplishing Your Goals

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Several years ago, I wrote an emotionally difficult article titled "Will I Reach My Goal?" It was about a book I was writing. The book describes my life and what it was like being hard of hearing in the 60s and 70s without any support in the schools. It covers my experiences…

Iron accelerates MDS progression

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In this issue of Blood, Antypiuk et al, utilizing a murine model, demonstrate that iron overload (IOL), accumulated via a mutation in the iron importer ferroportin, accelerates the myelodysplastic syndrome (MDS) phenotype, leading to exacerbation of marrow failure, inferior…

How I Treat Higher-Risk MDS with Alain Mina, Rami S. Komrokji

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Myelodysplastic syndromes/neoplasms (MDS) are a widely heterogenous group of myeloid malignancies characterized by morphologic dysplasia, a defective hematopoiesis, and recurrent genetic abnormalities. The original and revised International Prognostic Scoring Systems (IPSS) have…
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