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Myelodysplastic syndromes
Myelodysplastic syndromes:
(my-eh-lo-diss-PLASS-tik SIN-dromez) A group of disorders where the bone marrow does not work well, and the bone marrow cells fail to make enough healthy blood cells. Myelo refers to the bone marrow. Dysplastic means abnormal growth or development. People with MDS have low blood cell count for at…
/neoplasms (MDS) are a widely…
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Axatilimab-csfr (Niktimvo), a CSF-1R–targeting agent that reduces the drivers of inflammation and
fibrosis
fibrosis:
(fie-BRO-suss) Scarring of tissue. Fibrosis of the bone marrow is an feature seen in some types of unclassified myeldysplastic syndrome (MDS).
, has been approved by the FDA in 9 mg and 22 mg vial sizes to treat adult and pediatric patients with
graft-versus-host…
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Panelists discuss how long-term analysis of the ELEMENTS trial reveals significant improvements in
red blood cell
red blood cell:
The most numerous type of blood cell in healthy people. Red blood cells contain hemoglobin, a protein that picks up oxygen in the lungs and brings it to cells in all parts of the body. Also called erythrocyte, RBC.
(RBC) transfusion burden and
hemoglobin…
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Watch these sessions 2024 Patient and Family Conference, held in partnership with the University of Chicago.
Aplastic Anemia
Advances in Treating PNH
Fatigue Management
Conference Event last updated
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In this issue of Blood, Pidala et al report on the results of a multicenter phase 2 trial, in which a
graft-versus-host disease (GVHD)
graft-versus-host disease (GVHD):
Also called GVHD, it is a common complication of bone marrow/stem cell transplantation. It is caused when the donor's immune cells, now in the patient, begin to see the the patient's body as…
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Azacitidine
Azacitidine:
It works by reducing the amount of methylation in the body. Methylation is a process that acts like a switch to turn off or “silence” genes in certain cells. When these genes (called tumor suppressor genes) are turned off, MDS cells and cancer cells can grow freely. Azacitidine is approved by the U…
and
venetoclax
venetoclax:
Venetoclax is…
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Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment for severe
aplastic anemia
aplastic anemia:
(ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells, white blood cells, and platelets. The term aplastic is a Greek word meaning not to form. Anemia is a condition that…
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It is being increasingly recognized that many patients with blood cancers harbor germline variants that increase cancer risk.1 For example, 14% of patients with
acute myeloid leukemia
acute myeloid leukemia:
(uh-KYOOT my-uh-LOYD loo-KEE-mee-uh) A cancer of the blood cells. It happens when very young white blood cells (blasts) in the bone marrow fail to mature. The blast cells stay in…
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2024 Patient and Family Conference in Los Angeles
Session Recordings:
Transplant for Aplastic Anemia and MDS
Emerging Therapies in High-Risk MDS
Cardiovascular Concerns after HCT
Supportive Care Management
Advances in the Therapy of PNH
Advances in Treating Lower-Risk MDS
Palliative Care
Living with Chronic GVHD
A Patient Story
Inherited Bone Marrow Failure Syndromes
Advances in…
Conference Event last updated
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Key Points
A 3-parameter CCRS model was devised specifically for patients diagnosed with clonal
cytopenia
cytopenia:
(sie-tuh-PEE-nee-uh) A shortage of one or more blood cell types. Also called a low blood count.
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The CCRS offers precise CCUS risk assessment for patient management and
clinical trial
clinical trial:
A type of research study that tests how a drug, medical…
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Abstract
TP53 is a tumor suppressor gene frequently mutated in human cancers and is generally associated with poor outcomes. TP53 mutations are found in approximately 5% to 10% of patients with
de novo
de novo:
(di-NO-vo) Brand new, referring to the first time something occurs. MDS that is untreated or that has no known cause is called de novo MDS.
acute myeloid leukemia
acute…
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Key Points
This study illustrates the survival benefits of abatacept combined with CNI/MTX in patients with hematologic malignancies undergoing HCT.
The addition of abatacept may provide an approach for alternative donor pool expansion when
HLA
HLA:
See human leukocyte antigen.
-identical sibling donors are unavailable.
Abstract
Abatacept plus calcineurin inhibitors/methotrexate (CNI/…
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Abstract
The genomics era has facilitated the discovery of new genes that predispose individuals to
bone marrow failure
bone marrow failure:
A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic anemia, myelodysplastic syndromes (MDS) and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can…
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This was a phase II trial, evaluating the safety/efficacy of high-dose IV-ascorbic acid in patients with TET2 mutant CCUS. Eight of 10 patients enrolled were eligible for response assessment. At week 20, there were no responses by IWG MDS criteria. NCT03418038
(pdf available at link)
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Summary
Background
Access to allogeneic haematopoietic stem-cell transplantation (HSCT) remains challenging for older patients (aged >60 years) with acute myeloid leukaemia. We aimed to evaluate the efficacy of
venetoclax
venetoclax:
Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other…
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Several national agencies, including the American Society of Clinical Oncology (ASCO), recommend the prescription of exercise for patients diagnosed with cancer.1,2 The evidence base for this recommendation is derived from studies that showed exercise-related improvements in patient-reported outcomes (PROs), treatment-associated adverse effects, cardiorespiratory fitness (CRF), and overall…
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Abstract
Acute myeloid leukemia
Acute myeloid leukemia:
(uh-KYOOT my-uh-LOYD loo-KEE-mee-uh) A cancer of the blood cells. It happens when very young white blood cells (blasts) in the bone marrow fail to mature. The blast cells stay in the bone marrow and become to numerous. This slows production of red blood cells and platelets. Some cases of MDS become…
(AML) is a heterogeneous…
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I tell people I'm unique - almost one of a kind. I am 40 years old and have recently been diagnosed with a rare type of MDS having an unusual deletion 12q cytogenetic abnormality, known MDS 12q (-), or MDS 12q minus. I was diagnosed in February of 2015 at age 38, however my health struggles began several years before that. I had been living in Alaska for nearly twenty-five years. In 2008, I…
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Due to the impact on the Tampa, Florida community and surrounding areas by Hurricanes Helene and Milton, the AAMDSIF Tampa Patient and Family conference has been cancelled.
We will be announcing future webinars so stay tuned for more information from us.
Our thoughts are with all of those impacted by these devastating storms.
Conference Event last updated
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Findings refute former consensus that pregnancies post-transplant are nearly impossible, highlight need for increased fertility counseling
(WASHINGTON, July 15, 2024) — Despite treatment-related fertility challenges, female patients can become pregnant and give birth to healthy children after undergoing allogeneic hematopoietic cell transplantation (alloHCT), according to a…
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